Safety
2005Baxter, J.H., J.L. Carlos, J. Thurmond, R.N. Rehani, J. Bultman, and D. Frost, 2005 Dietary toxicity of calcium ß-hydroxy-ß-methylbutyrate (CaHMB), Food & Chem. Toxicology 43:1731-1741 Toxicity study conducted in rats fed up to five percent HMB in the diet.
The data showed that HMB at five percent of the diet can be considered the NOAEL (no observed adverse effect level). This amounted to ~3.5 and ~4.1 g/kg body weight intake per day in male and female rats, respectively. (Like a normal human consuming about 300 g per day.)
The data showed that HMB at five percent of the diet can be considered the NOAEL (no observed adverse effect level). This amounted to ~3.5 and ~4.1 g/kg body weight intake per day in male and female rats, respectively. (Like a normal human consuming about 300 g per day.)
view abstract2000Nissen, S., R.L. Sharp, L. Panton, M. Vukovich, S. Trappe, and J.C. Fuller, Jr., 2000 ß-Hydroxy-ß-methylbutyrate (HMB) supplementation in humans is safe and may decrease cardiovascular risk factors, J. Nutr. 130:1937-1945 A summary of safety data from nine double-blind randomized clinical trials including both men and women and young and elderly adults.
HMB supplementation was shown to have no adverse or untoward effects. This summary also shows that HMB supplementation has positive effects on LDL cholesterol (-7.3 percent) and systolic blood pressure (-4.4 mm Hg).
HMB supplementation was shown to have no adverse or untoward effects. This summary also shows that HMB supplementation has positive effects on LDL cholesterol (-7.3 percent) and systolic blood pressure (-4.4 mm Hg).
Gallagher, P.M., J.A. Carrithers, M.P. Godard, K.E. Schulze, and S.W. Trappe, 2000 ß-Hydroxy-ß-methylbutyrate (HMB) ingestion, Part II: effects on hematology, hepatic and renal function, Med. & Sci. in Sports & Exer. 32:2116-2119 Double-blind randomized study with male weightlifters.
In this eight-week study, consuming up to six grams of HMB per day was shown to have no adverse effects on measures of hematology and hepatic and renal function.
In this eight-week study, consuming up to six grams of HMB per day was shown to have no adverse effects on measures of hematology and hepatic and renal function.
